Adult Brainstem Gliomas Sylvia C. Eisele, MD; and David A. Reardon, MD Brainstem gliomas in adults are a rare and heterogeneous group of brain tumors that vary with regard to underlying pathology, radio-graphic appearance, clinical course and prognosis. Diffuse intrinsic pontine gliomas represent the most common subtype. AlthoughCited by: A diffuse intrinsic pontine glioma (DIPG) is a tumour located in the pons (middle) of the brain stem. Glioma is a general name for any tumour that arises from the supportive tissue called glia, which help keep the neurons in place and functioning well. DIPG is a brainstem xvibrator.xyz brain stem is the bottommost portion of the brain, connecting the cerebrum with the spinal cord.
A significant proportion of diffuse intrinsic pontine gliomas in children or younger adults are also members of this molecular subtype. In addition to the clinical and radiographic findings, this diagnosis is confirmed by molecular testing (either immunohistochemistry or DNA sequencing) that demonstrates the characteristic H3K27M mutation in. Diffuse Intrinsic Pontine Glioma (DIPG) Eligibility: Diagnosis of progressive diffuse intrinsic pontine glioma (DIPG) or an increase in the bi-dimensional measurement or the appearance of a new tumor lesion since diagnosis; At least 2 but not more than 22 years old; Able to swallow capsules whole.
This article includes discussion of brainstem gliomas in adults, diffuse midline glioma, diffuse midline glioma with histone mutation, H3 K27M mutant glioma, high-grade midline glioma with H3 K27M mutation, medullary glioma, midbrain glioma, pontine glioma, cystic brainstem glioma, diffuse brainstem glioma, exophytic brainstem glioma, and focal brainstem glioma. Diffuse Intrinsic Pontine Glioma, commonly referred to as pontine glioma, infiltrative brainstem glioma, or DIPG, is a rare tumor of the brainstem that occurs almost exclusively in children. A pontine glioma occurs in a most delicate area of the brainstem (the "pons"), which controls many critical functions, including breathing and blood pressure.
Brainstem gliomas, which are rare in adults, account for approximately 15 percent of childhood brain tumors. Approximately 80 percent of brainstem tumors are diffuse intrinsic pontine glioma (DIPG), which has a very poor prognosis. DIPG, also commonly known as a pontine glioma (located at the pons part of the brainstem), or infiltrative. Gliomas can affect all ages, but they are most often seen in adults. Gliomas are slightly more likely to occur in men than in women, and more common in Caucasians than in African Americans. There are different grades of gliomas, indicating their growth potential and aggressiveness. This group of tumors includes glioblastomas.