Five types of region and organ-specific multipotent adult stem cells have been identified in the Drosophila digestive system: intestinal stem cells (ISCs) in the posterior midgut; Adult stem cells maintain tissue homeostasis by continuously replenishing damaged, aged and dead cells in Cited by: 9. Nov 15, · The precursors for intestinal stem cells (ISCs), called adult midgut progenitors (AMPs), first appear in the embryonic Drosophila midgut epithelium amongst a small number of diploid cells that are set aside to generate the future adult midgut epithelium during xvibrator.xyz by:
Apr 24, · Singh SR, Zeng X, Zheng Z, Hou SX () The adult Drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus). Cell Cycle 10 (7)– Google Scholar Cited by: 9. Jul 11, · The adult Drosophilaintestinal epithelium constitutes a productive, genetically accessible model system to study the maintenance of epithelial homeostasis, regenerative capacity, and stem cell function (Biteau et al., ).Cited by:
Distinct populations of stem cells (SCs) regenerate specialized epithelia in the intestine. How their regional identities are maintained remains unclear. Here, Jasper and colleagues find that BMP/Dpp signaling diversifies regeneration in the adult Drosophila gut. Dpp forms a gradient that directs regeneration of acid-producing copper cells (CCs) from gastric xvibrator.xyz by: Sep 18, · In conclusion, research investigating stem cell behavior in the adult Drosophila gastrointestinal epithelium has experienced tremendous progress, which, from a clinical perspective, may allow us to elucidate the pathogenesis of different gastrointestinal and metabolic disorders in Cited by: 6.
As in the case of the mammalian intestine, the adult Drosophila midgut is constantly self-renewed by its resident stem cells (ISCs) (Ohlstein and Spradling, ) (Micchelli and Perrimon, ). Normal self-renewal of the intestinal epithelium requires a tight regulation of the activity of multiple conserved signalling pathways (Fig. 2A).Cited by: Studies of the adult Drosophilamidgut have led to many insights in our understanding of cell-type diversity, stem cell regeneration, tissue homeostasis, and cell fate decision. Advances in single-cell RNA sequencing provide opportunities to identify new cell types and molecular features.